A.P. Bio is an American television sitcom that premiered on February 1, 2018, on NBC as a mid-season replacement. It aired on NBC for two seasons until June 13, 2019 and moved to Peacock for its subsequent seasons. The series is focused on the everyday lives of the faculty and students of the fictitious Whitlock High School. Mike O'Brien created the series and is a recurring writer. O'Brien is also one of the executive producers alongside Seth Meyers, Lorne Michaels, Andrew Singer, and Michael Shoemaker. Although set in Toledo, Ohio, it is primarily filmed in Los Angeles, California.

The series is centered around Jack Griffin, played by Glenn Howerton. Griffin is a philosophy professor who, after being fired from his Harvard position, returns to his hometown and picks up teaching Advanced Placement Biology all while trying to find opportunities to move out. A.P. Bio also features a cast of Lyric Lewis, Mary Sohn, Jean Villepique, Paula Pell, and Patton Oswalt.

A.P. Bio was met with mixed reviews on its first season; however, following seasons have garnered a much more positive reception. In December 2021, the series was canceled after four seasons.