Three Moons Over Milford is an American science fiction dramedy television series set in a picturesque small town in southern Vermont. Shortly before the series begins, an asteroid hits the Moon, shattering it into three fragments, threatening to eventually fall to Earth and end life. Thus, the continuous threat of an imminent "Judgment Day" causes many people to question their lives and live them to extremes by quitting jobs, indulging vices and living as if each day were their last.

The show was cancelled because of low ratings in September 2006.