Big Guy and Rusty the Boy Robot, also known as The Big Guy and Rusty, is an American animated TV series based on the comic book of the same name by Frank Miller and Geof Darrow.The series ran for 26 episodes and featured the voice of Pamela Adlon (credited as Pamela Segall) as the voice of Rusty, Jonathan David Cook as Big Guy, and the voices of Gabrielle Carteris, Stephen Root, Kathy Kinney, Kevin Michael Richardson, M. Emmet Walsh, and R. Lee Ermey. A line of toys based on the show was produced by Bandai, along with ephemera surrounding a brief promotional tie-in with Burger King.

26 episodes were produced for the Fox Kids Network's Saturday morning lineup, but the channel cancelled the show after six episodes. The show premiered on September 18, 1999, and ended on October 23. This left twenty episodes unaired for more than a year. Starting in January 2001, Fox Kids added the show to its weekday-afternoon block, and aired all twenty-six existing episodes. The entire series was later broadcast on ABC Family in 2002.

On July 12, 2016, Amazon released the complete series on DVD-R.