The Marilyn Denis Show is a Canadian daytime television talk show which debuted on January 10, 2011, on CTV and CTV 2 (formerly A-Channel). Hosted by Marilyn Denis, the show airs weekdays at 10 a.m. on CTV and 11 a.m. ET on CTV 2 (timeslots vary in other time zones).

The show has a lifestyle-oriented format similar to Denis's previous Citytv talk show CityLine, but also regularly features celebrity entertainment guests, which are not commonplace on the Citytv program. Denis had left CityLine in 2008 following the split of the assets of CHUM Limited (Denis was primarily employed as morning co-host on CHUM-FM, which was retained by CTV, whilst her secondary employer Citytv was acquired by Rogers). The current program is produced in the same Toronto building (at 299 Queen Street West) in which CityLine was based during Denis's tenure, in the same studio as CityLine which was renovated specifically for the show.

On November 17, 2015, the show celebrated its 1,000th episode.

On April 13, 2023, Denis announced her decision to end the show after its 13th season, with the final episode slated to air June 9, 2023. The day before the show's final episode, CTV announced that Mary Berg will host a new lifestyle talk show, The Good Stuff with Mary Berg, in the 2023-24 television season.The final episode featured a tribute video narrated by Denis's son Adam Wylde, surprise appearances by Andrea Martin and Eugene Levy, a farewell gathering of many of the guest experts who had been regular contributors to the program, and a musical performance by Glass Tiger of their 1980s pop classic "Don't Forget Me (When I'm Gone)".