It's Your Chance of a Lifetime is an American game show that aired on Fox in June 2000. Gordon Elliott hosted the show, with Mark Thompson serving as announcer (only to do the opening intro and contestant call-in at the end).

The show was an adaptation of the Australian game show The $1,000,000 Chance of a Lifetime; the name was changed in the United States because an unrelated 1980s game show had already used the name.