Poison Ivy is a 1992 American erotic thriller film directed by Katt Shea. It stars Drew Barrymore, Sara Gilbert, Tom Skerritt and Cheryl Ladd. The original music score is composed by David Michael Frank. The film was shot in Los Angeles.

It was nominated for the 1992 Grand Jury prize of Best Film at the Sundance Festival. Sara Gilbert was nominated for Best Supporting Female at the 1993 Independent Spirit Awards. Although it did not fare very well at the box office, grossing $1,829,804 with its limited theatrical release to 20 movie theaters, the film received favorable word-of-mouth, and became a success on cable and video in the mid-1990s. It is the first installment in a Poison Ivy film series that includes three direct-to-video sequels.