Mary-Louise Parker (born August 2, 1964) is an American actress. After making her Broadway debut as Rita in Craig Lucas's Prelude to a Kiss in 1990 (for which she received a Tony Award nomination), Parker came to prominence for film roles in Grand Canyon (1991), Fried Green Tomatoes (1991), The Client (1994), Bullets over Broadway (1994), A Place for Annie (1994), Boys on the Side (1995), The Portrait of a Lady (1996), and The Maker (1997). Among stage and independent film appearances thereafter, Parker received the 2001 Tony Award for Best Actress in a Play for her portrayal of Catherine Llewellyn in David Auburn's Proof, among other accolades. Between 2001 and 2006, she recurred as Amy Gardner in the NBC television series The West Wing, for which she was nominated for the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2002. She received both a Golden Globe and a Primetime Emmy Award for her portrayal of Harper Pitt in the acclaimed HBO television miniseries Angels in America in 2003.Parker went on to enjoy large success as Nancy Botwin, the lead character in the television series Weeds, which ran from 2005 to 2012 and for which she received three nominations for the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series between 2007 and 2009 and received the Golden Globe Award for Best Actress – Television Series Musical or Comedy in 2006.Her later film appearances include roles in The Spiderwick Chronicles (2008), Red (2010), R.I.P.D. (2013), and Red 2 (2013). Parker returned to Broadway in 2019 to star in The Sound Inside, for which she won her second Tony Award for Best Actress in a Play. Since 2007, Parker has contributed articles to Esquire magazine and published her memoir, Dear Mr. You, in 2015. In 2017, she starred as Roma Guy on the ABC television miniseries When We Rise. In 2018, she appeared as a political consultant in the show Billions on Showtime.