Pain Hustlers is a 2023 American crime drama film directed by David Yates from a screenplay by Wells Tower, based on the 2022 book of the same name by Evan Hughes, which tells the inside story of a band of entrepreneurial upstarts (Insys Therapeutics) who made millions selling painkillers—until their scheme unraveled, putting them at the center of a landmark criminal trial. The film stars Emily Blunt, Chris Evans, Andy García, Catherine O'Hara, Jay Duplass, Brian d'Arcy James, and Chloe Coleman. Its plot centers on a high school dropout who lands a job with a failing pharmaceutical company in Central Florida, where she soon finds herself at the center of a criminal conspiracy.

Pain Hustlers had its world premiere at the Toronto International Film Festival on September 11, 2023, and was released in select theaters in the United States on October 20, 2023, before its streaming debut by Netflix on October 27, 2023.