A Pinky and the Brain Christmas is a 1995 animated television special based on the Pinky and the Brain TV series. It is directed by Rusty Mills and features the voices of Rob Paulsen and Maurice LaMarche. It is about the eponymous genetically modified mice, who are bent on world domination, attempting to deceive Santa Claus into delivering hypnotic devices as presents during Christmas.

Although released on DVD with season 1 of the series, A Pinky and the Brain Christmas was originally aired December 13, 1995 on The WB as a prime time special. It won the Primetime Emmy Award for Outstanding Animated Program.