Gloria's Romance is a 1916 American silent film serial starring Billie Burke. Serial films, also called chapter plays, were shorter films that were typically run before the main feature film, each of which was part of a longer story, and ended in a cliffhanger, thus encouraging the audience to return every week.

The film was Burke's second outing as a film actress, and one of the very rare occasions in which a Broadway performer of her magnitude starred in a chapter play. In its original form, this serial comprised 20 chapters and was 40 reels long, which was several chapters longer than most film serials of the time.

Gloria's Romance marked the debut of actor Richard Barthelmess. It was written by Rupert Hughes and his wife and produced by George Kleine. Walter Edwin and Colin Campbell served as principal directors. It is a lost film.