The 2005 Genesis was a professional wrestling pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA) promotion that took place on November 13, 2005 at the Impact Zone in Orlando, Florida. It was the first event under the Genesis name and eleventh event in the 2005 TNA PPV schedule. Seven professional wrestling matches and two pre-show matches were featured on the event's card, one of which involved a championship.

The main event was a Six Man Tag Team match pitting the team of Rhino and Team 3D (Brother Ray and Brother Devon) against the team of Jeff Jarrett and America's Most Wanted (Chris Harris and James Storm). Rhino and Team 3D won the encounter. The TNA X Division Championship was defended by then-champion A.J. Styles against the challenger Petey Williams at the event. Styles defeated Williams to retain the championship. A No Disqualification match between Abyss and Sabu was held at the show. Abyss won the contest. A match to determine the number-one contender to the NWA World Heavyweight Championship took place at Genesis, in which Monty Brown defeated Jeff Hardy for a future title match.

Genesis is remembered for the debut of Christian Cage. It was also dedicated to World Wrestling Entertainment (WWE) wrestler Eddie Guerrero, who died the day of the show. Cage's debut was ranked by TNA as the 5th greatest moment in the company's history. Corey David Lacroix of the professional wrestling section of the Canadian Online Explorer rated the show an 8 out of 10, higher than the 2006 edition of 5 out of 10 by Bob Kapur.

In October 2017, with the launch of the Global Wrestling Network, the event became available to stream on demand.