Injun Trouble is a 1969 Merrie Melodies cartoon, directed by Robert McKimson. The cartoon was released on September 20, 1969, and features Cool Cat. It is noted for being the last cartoon in the original Merrie Melodies series, ending a run that had continued since 1931, as well as the whole original Looney Tunes/Merrie Melodies series from 1930-1969. Additionally, this was the 1,000th cartoon short released by Warner Bros.

This cartoon was the last Merrie Melodies cartoon until The Fright Before Christmas ten years later in 1979. This cartoon was also the last Warner Bros. cartoon to be produced by Warner Bros.-Seven Arts Animation before the studio shut down on October 10, 1969 when Warner Bros.-Seven Arts was owned by Kinney National Company until Warner Bros. Animation reopened its animation department on March 15, 1980, and the second of the only two Cool Cat shorts directed by Robert McKimson, as well as the last Warner Bros. cartoon to be directed by him. The cartoon shares its name with an earlier short directed by Bob Clampett, which features Porky Pig.