Flesh and Blood is a 1922 American silent drama film directed by Irving Cummings and starring Lon Chaney, Noah Beery, Edith Roberts and De Witt Jennings. The film originally had a color flashback scene with Chinese actors, but the color footage is no longer in any of the available prints. The film's working titles were Prison and Fires of Vengeance. Interior scenes were shot at Universal Studios.

The popular song, "Just a Song at Twilight" is featured prominently in the film, and was usually performed by the accompanists as the main musical theme for the film. Due to an oversight, the film was never properly copyrighted. The film was rereleased theatrically in 1927.

A print of the film is held at the George Eastman House in Rochester, New York. A still exists showing Lon Chaney visiting his daughter at the mission (see plot)