One Little Pill is a documentary film about the use of generic medications (primarily naltrexone, but also nalmefene) for treating and curing alcoholism. The primary focus is on the so-called Sinclair method, which pairs these medications with continued drinking. It was produced by Zard Productions as a film project for the C Three Foundation and released on Vimeo and VHX for on-demand viewing in October 2014. As of August 2015, DVD-R copies are also available.