Wheel of Fortune (often known simply as Wheel) is an American television game show created by Merv Griffin. The show has aired continuously since January 1975. It features a competition in which contestants solve word puzzles, similar to those in hangman, to win cash and prizes determined by spinning a giant carnival wheel. The current version of the series, which airs in nightly syndication, premiered on September 19, 1983. It stars Pat Sajak and Vanna White as hosts, who have hosted the nighttime version since its inception. The original version of Wheel was a network daytime series that ran on NBC from January 6, 1975, to June 30, 1989, and subsequently aired on CBS from July 17, 1989, to January 11, 1991; it returned to NBC on January 14, 1991, and was cancelled that year, ending on September 20, 1991. (The network daytime and syndicated nighttime versions aired concurrently from 1983 until the former's conclusion.)

The network version was originally hosted by Chuck Woolery and Susan Stafford. Woolery left in 1981, and was replaced by Sajak. Sajak left the network version in January 1989 to host his own late-night talk show, while remaining as host of the nighttime Wheel. Sajak was replaced in the daytime by Rolf Benirschke, who was in turn replaced by Bob Goen when the network show moved to CBS. Goen remained as host for the second NBC run. Stafford left in 1982 and was replaced by White, who remained on the network show for the rest of its run. The show has also had four announcers in its history: Charlie O'Donnell, Jack Clark, M. G. Kelly, and Jim Thornton.

Two spin-off versions exist as well. The first was Wheel 2000, a version featuring child contestants which aired simultaneously on CBS and Game Show Network between 1997 and 1998. This version's hosts were David Sidoni and Tanika Ray, the latter in the role of a CGI hostess named "Cyber Lucy". The second, Celebrity Wheel of Fortune, began airing on ABC on January 7, 2021, and features celebrities playing a modified version of the game with winnings donated to charity.

Wheel of Fortune ranks as the longest-running syndicated game show in the United States, with 7,000 episodes taped and aired as of May 10, 2019. TV Guide named it the "top-rated syndicated series" in a 2008 article, and in 2013, the magazine ranked it at No. 2 in its list of the 60 greatest game shows ever. The program has also come to gain a worldwide following with 60 international adaptations. The syndicated series' 41st season premiered on September 11, 2023. With the show's 36th season in 2018, Sajak became the longest-running host of any game show, surpassing Bob Barker, who hosted The Price Is Right from 1972 to 2007.In June 2023, Sajak announced his retirement from the show after the 41st season beginning in September 2023, with Ryan Seacrest confirmed to replace him. It has been confirmed that Vanna White will remain on the show, despite Sajak's upcoming departure.