Frank and Penelope is a 2022 American romantic crime film written and directed by Sean Patrick Flanery. The film stars Billy Budinich, Caylee Cowan, Kevin Dillon, Donna D'Errico, Lin Shaye, Johnathon Schaech, and Sean Patrick Flanery. The film is a road movie that begins in the city of Austin, Texas traveling along a deserted stretch of dirt road miles from civilization. It then takes place in the ghost town of Terlingua, Texas which devolves into chaos and violence after it is discovered that the proprietor of the motel and diner, Chisos, is a psychotic, cannibal along with his sadistic family. Frank and Penelope suddenly become immersed in a hellish nightmare, on a life and death journey, where escape is just a heart-pounding breath away.

Frank & Penelope had its world premiere at the Riviera International Film Festival in Italy on May 14, 2022. It's also been screened as part of the Cannes Film Festival market where Fabrication Films acquired film rights. Frank & Penelope was theatrically released in the United States on June 3, 2022.