Melissa P. is a 2005 erotic drama film directed by Luca Guadagnino, from a screenplay by Guadagnino, Barbara Alberti and Cristiana Farina and a screen story by Guadagnino and Farina. It is based on the 2003 semi-autobiographical novel 100 colpi di spazzola prima di andare a dormire (One Hundred Strokes of the Brush Before Bed) by Melissa Panarello. The film stars María Valverde, Fabrizia Sacchi, Primo Reggiani, Nilo Mur, Elio Germano, Letizia Ciampa, Davide Pasti, Alba Rohrwacher, Piergiorgio Bellocchio, Giulio Berruti, Marcello Mazzarella, Claudio Santamaria and Geraldine Chaplin.

The film was released by Columbia Pictures in Italy on 18 November 2005 and in Spain on 24 February 2006. It placed at number one at the box office in Italy.