The Sisters Brothers is a 2018 Western film directed by Jacques Audiard from a screenplay he co-wrote with Thomas Bidegain, based on the novel of the same name by Patrick deWitt. An American and French co-production, it is Audiard's first English-language work. The film stars John C. Reilly (who also produced) and Joaquin Phoenix as the notorious assassin brothers Eli and Charlie Sisters, and follows the two brothers as they chase after two men (Jake Gyllenhaal and Riz Ahmed) who have banded together to search for gold.

The film had its world premiere at the Venice International Film Festival on 2 September 2018, where it won the Silver Lion for Best Direction, and was theatrically released in the United States on 21 September 2018. The Sisters Brothers received positive reviews from critics, with most praise going to its performances, characters, direction and soundtrack. It was a box office bomb, grossing $13.1 million against its $38 million production budget. It was the final feature film featuring Rutger Hauer released before his death, although he had finished filming several projects released after his passing.