Chain Reaction is an American television game show created by Bob Stewart, in which players compete to form chains composed of two-word phrases.

The show has aired five separate runs: Bill Cullen hosted the original series on NBC from January 14 to June 20, 1980. The second version aired on the USA Network from September 29, 1986, to December 27, 1991, and was hosted first by Blake Emmons and later by Geoff Edwards (who also subbed for Cullen for two weeks on the NBC version). A third version aired on Game Show Network from August 1, 2006, to June 9, 2007, hosted by Dylan Lane. A fourth version also on GSN was announced on January 26, 2015, with Vincent Rubino as executive producer and hosted by Mike Catherwood. Forty episodes were ordered for Catherwood's version, which aired from July 16, 2015, to January 29, 2016. The most recent version, also on GSN, was announced in November 2020, with Mike Richards as executive producer, Ed Egan as showrunner and Lane returning as host, it aired from February 22, 2021 to June 20, 2022.