Captain Underpants: The First Epic Movie is a 2017 American animated superhero comedy film based on Dav Pilkey's children's novel series Captain Underpants, produced by DreamWorks Animation and distributed by 20th Century Fox. It was directed by David Soren from a screenplay by Nicholas Stoller, and stars the voices of Kevin Hart, Ed Helms, Thomas Middleditch, and Nick Kroll. The film was released during the 20th anniversary of the Captain Underpants series. In the film, fourth-grade pranksters George and Harold hypnotize their humorless principal Mr. Krupp into thinking he is a superhero named Captain Underpants. The movie loosely adapts the first, second, fourth, and eleventh Captain Underpants books.

Captain Underpants: The First Epic Movie premiered on May 21, 2017, at the Regency Village Theater in Los Angeles, and was released in the United States on June 2 in 3D and 2D formats. The film received generally positive reviews, with critics praising the animation, humor, faithfulness, and references to its source material, and voice acting, particularly from Helms. It grossed $125 million worldwide against a budget of $38 million, the lowest budget for a DreamWorks Animation feature film until Spirit Untamed, which had a budget of $30 million.The film was the last to be distributed by 20th Century Fox. Following NBCUniversal's acquisition of DreamWorks Animation in 2016, Universal Pictures began distributing DreamWorks's films, starting with How to Train Your Dragon: The Hidden World (2019).

A Netflix television series, The Epic Tales of Captain Underpants, aired from 2018 to 2020, while a spin-off film, Dog Man, is set to release on January 31, 2025 by Universal.