Stuart Little is a 1999 American live-action/animated fantasy comedy film loosely based on the 1945 novel Stuart Little by E. B. White. Directed by Rob Minkoff in his live-action debut, the screenplay was written by M. Night Shyamalan and Greg Brooker, and stars Geena Davis, Hugh Laurie and Jonathan Lipnicki, alongside the voices of Michael J. Fox, Nathan Lane, Chazz Palminteri, Steve Zahn, Bruno Kirby and Jennifer Tilly.

Stuart Little premiered in Westwood at Mann Village Theatre on December 5, 1999, and was released in United States on December 17, 1999, by Columbia Pictures. The film received generally positive reviews, and was nominated for an Academy Award for Best Visual Effects, but lost to The Matrix. After its success, it also started a franchise, spawning the sequel Stuart Little 2 in 2002, the short-lived television series Stuart Little in 2003, and another sequel in 2005, the direct-to-video Stuart Little 3: Call of the Wild. It was Estelle Getty's final film role.