Scream is a 2022 American slasher film directed by Matt Bettinelli-Olpin and Tyler Gillett, and written by James Vanderbilt and Guy Busick. It is the fifth installment in the Scream film series and a direct sequel to Scream 4 (2011). The first in the series not directed by Wes Craven, who died in 2015, the film is dedicated to Craven at the beginning of the closing credits. The film stars Melissa Barrera, Kyle Gallner, Mason Gooding, Mikey Madison, Dylan Minnette, Jenna Ortega, Jack Quaid, Jasmin Savoy Brown, and Sonia Ammar, with Marley Shelton, Skeet Ulrich, Roger L. Jackson, Heather Matarazzo, Courteney Cox, David Arquette, and Neve Campbell reprising their roles from previous installments. The plot takes place twenty-five years after the original Woodsboro murders from Scream (1996), when yet another Ghostface appears and begins targeting a group of teenagers who are each somehow linked to the original killings.

Although fifth and sixth Scream installments were discussed after the release of Scream 4 in 2011, Craven, writer Kevin Williamson, and executive producer Harvey Weinstein had doubts about proceeding with more films following the less-than-expected box office performance of the fourth film. After the 2017 sexual assault allegations against Weinstein and the closure of The Weinstein Company, the rights to the Scream franchise were obtained by Spyglass Media Group in November 2019, who confirmed a new film would later be made. The following year, Williamson, who was returning as an executive producer, confirmed the film would not be a reboot and that Betinelli-Olpin and Gillett had been hired in March 2020 to direct the film. Campbell and Arquette were confirmed to be returning later that month, with Cox and the new cast members joining throughout the middle of the year. Filming took place between September and November 2020 in North Carolina. To avoid any plot leaks, numerous versions of the screenplay were produced and several additional scenes were filmed.

Scream was released in the United States on January 14, 2022, by Paramount Pictures. The film received generally positive reviews from critics, who praised the direction, performances (particularly Campbell's) and tribute to Craven, with some calling it the best Scream sequel. It was also a box-office success, grossing over $138 million against a production budget of $24 million. A sequel, Scream VI, was released in March 2023.